How to stop snoring

Research has revealed that people who snore have obstructive sleep apnea, which could increase the risk of developing heart disease. Snoring can be minimized or stopped in different ways. Sleeping on  side stops the base of  tongue and soft palate from collapsing to the back wall of throat that usually happens when sleeping on the back. This usually results in a vibrating sound when a person is asleep.

If sleeping on the side is difficult, a body pillow or taping tennis balls to the back of pyjamas can be a solution. Losing weight can help people who have recently gained weight and have started to snore as a result. Thin people do snore, but weight gain can occasionally squeeze the diameter of the throat, again causing it to collapse during sleep.

Drinking alcohol four or five hours before sleeping can make snoring worse and louder as it can reduce the resting tone of the muscle in the back of the throat. Some people who do not usually snore can sometimes snore after drinking. Lack of sleep can also play a significant part in the increase of snoring as, when a tired person goes into a deep sleep, muscles become floppier.

Opening nasal passages can minimize snoring if you have  cold or if your nose is blocked. A hot shower, a neti pot or nasal strips can help clear passages before bed. Replacing pillows can reduce allergens and dust mites that are present in the bedroom that may be contributing to snoring.

Sleep apnea, or obstructive sleep apnea OSA is a long-term condition and may require lifelong treatment for people who suffer from it. In most cases, this would mean losing weight, stopping smoking, limiting alcohol consumption and avoiding sedation and sleeping tablets, as well as sleeping on side instead of back.

People with moderate to severe OSA may have to use a continuous positive airway pressure CPAP device, which is a small pump that provides a continuous supply of compressed air through a mask that covers the nose and the mouth. Another treatment method is the mandibular advancement device MAD which is a dental appliance similar to a gum shield. It is worn over the teeth when you are asleep and aims to hold the jaw and tongue forward to increase the space at the back of the throat.
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How alcohol causes dementia

Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study of over one million adults diagnosed with dementia in France.

This study looked specifically at the effect of alcohol use disorders and included people who had been diagnosed with mental and behavioural disorders or chronic diseases that were attributable to chronic harmful use of alcohol. Of the 57,000 cases of early-onset dementia (before the age of 65), the majority (57%) were related to chronic heavy drinking.

The World Health Organization (WHO) defines chronic heavy drinking as consuming more than 60 grams pure alcohol on average per day for men and 40 grams per day for women. Heavy drinking and alcohol use disorders are the most important risk factors for dementia, and especially important for those types of dementia which start before age 65, and which lead to premature deaths," says study co-author and Director of the CAMH Institute for Mental Health Policy Research Dr. Jürgen Rehm.

Alcohol-induced brain damage and dementia are preventable, and known-effective preventive and policy measures can make a dent into premature dementia deaths. Alcohol use disorders shorten life expectancy by more than 20 years, and dementia is one of the leading causes of death. For early-onset dementia, there was a significant gender split.

Alcohol use disorders were also associated with all other independent risk factors for dementia onset, such as tobacco smoking, high blood pressure, diabetes, lower education, depression, and hearing loss, among modifiable risk factors. It suggests that alcohol use disorders may contribute in many ways to the risk of dementia.
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Hormonal imbalances can cause excess weight in different parts of the body

Latest research shows excess weight may gather in certain areas regardless of how much you diet or exercise, as a result of hormone imbalances. Lifestyle, diet and genetics play a part. Human bodies evolved to react to danger by producing the stress hormone cortisol, to trigger the release of energy for the ‘fight or flight’ response. Excess cortisol sparks the release of energy in the form of fat and glucose. This is redeposited as fat round the waist.

Eat little and often to keep blood sugar levels stable, as fluctuations can trigger cortisol release.  Eat foods with a low glycemic load, such as apples, wholegrain bread or cashews, which slowly release energy. Too much oestrogen can cause fat to build in the buttocks and thighs. Those fat cells manufacture more oestrogen, and, in turn, more fat is stored. Drinking too much alcohol means the liver can’t clear oestrogen from the blood.

Fat ankles are often the result of fluid retention, which can be caused by a lack of progesterone. Progesterone acts as a diuretic, flushing excess liquid from the body. Bulging calves may be made worse by low levels of human growth hormone, which seems to prompt fat storage in the legs.

Foods rich in vitamin E may boost progesterone. These include sunflower seeds and peanut butter. Reduce sodium intake as this is key in regulating blood pressure and fluid levels, which can help with water retention in the legs and ankles. Avoid processed food such as ready meals. And to boost human growth hormone, get plenty of sleep-HGH is only released at night in adults.

A chubby face, as well as a flabby neck, could be down to too little thyroxine, a hormone produced by the thyroid gland. An underactive thyroid slows the metabolism, which may cause bloating. Another symptom is a swollen neck, called goitre, where the thyroid gland becomes a visible bump. Taking a supplement with selenium, which helps body use thyroxine more efficiently.

Human produces a hormone called DHEA (dehydroepiandrosterone), which is converted into testosterone-DHEA helps build lean muscle mass. When testosterone levels drop too low, muscle mass can be replaced with fat-this is noticeable on the upper arms, which have large muscles.
Women's testosterone levels drop with age, peaking in their 20s, then halving by menopause, but certain foods can help. Consume more protein, such as fish, eggs, tofu and nuts. Zinc, magnesium and vitamin B6 also promote testosterone production.

The rolls that hang over the back of your bra could be because of low levels of human growth hormone (HGH). During the night, women’s pituitary glands release human growth hormone, which stimulates fat cells to release energy to repair the body’s tissues. Too little HGH and fat cells don’t receive the message to convert fat into energy. Studies show adults who lack HGH often have a high level of body fat around the trunk, especially the back.

Melatonin-rich foods, such as raspberries, can increase HGH secretion by up to 157 per cent. Melatonin triggers the release of hormones that tell the body it’s time for sleep. Another study found foods high in the amino acid glutamine, such as yoghurt, can raise HGH production.
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Why people get aggressive after drinking

Researchers have used magnetic resonance imaging (MRI) scans that measure blood flow in the brain to understand why people become aggressive and violent after drinking alcohol. After only two drinks, the researchers noted changes in the working of the prefrontal cortex of the brain, the part involved in tempering a person's levels of aggression. The study was led by Thomas Denson of the University of New South Wales in Australia in the journal Cognitive, Affective, & Behavioral Neuroscience.

According to most theories, alcohol-related aggression is caused by changes in the prefrontal cortex. However, there is a lack of substantial neuroimaging evidence to substantiate these ideas. In this study, Denson and his team recruited fifty healthy young men. The participants were either given two drinks containing vodka, or placebo drinks without any alcohol. While lying in an MRI scanner, the participants then had to compete in a task which has regularly been used over the past 50 years to observe levels of aggression in response to provocation.

The functional magnetic resonance imaging allowed the researchers to see which areas of the brain were triggered when the task was performed. They could also compare the difference in scans between participants who had consumed alcohol and those who hadn't. Being provoked was found to have no influence on participants' neural responses. However, when behaving aggressively, there was a dip in activity in the prefrontal cortex of the brains of those who had consumed alcoholic drinks. This dampening effect was also seen in the areas of the brain that are involved reward. Also, heightened activity was noted in the hippocampus, the part of the brain associated with people's memory.

Although there was an overall dampening effect of alcohol on the prefrontal cortex, even at a low dose of alcohol there is a significant positive relationship between dorsomedial and dorsolateral prefrontal cortex activity and alcohol-related aggression. These regions may support different behaviors, such as peace versus aggression, depending on whether a person is sober or intoxicated.

The results are largely consistent with a growing body of research about the neural basis of aggression, and how it is triggered by changes in the way that the prefrontal cortex, the limbic system and reward-related regions of the brain function. The results of the current study are also consistent with several psychological theories of alcohol-related aggression.
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How alcohol damages DNA and causes cancer

Scientists have shown how alcohol damages DNA in stem cells, helping to explain why drinking increases the risk of cancer, according to latest research. Researchers used mice to show how alcohol exposure leads to permanent genetic damage. Scientists at the MRC Laboratory of Molecular Biology, Cambridge, gave diluted alcohol, chemically known as ethanol, to mice.

They then used chromosome analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol. They found that acetaldehyde can break and damage DNA within blood stem cells leading to rearranged chromosomes and permanently altering the DNA sequences within these cells.

It is important to understand how the DNA blueprint within stem cells is damaged because when healthy stem cells become faulty, they can give rise to cancer. These new findings therefore help us to understand how drinking alcohol increases the risk of developing 7 types of cancer including common types like breast and bowel.

Some cancers develop due to DNA damage in stem cells while some damage occurs by chance. The study also examined how the body tries to protect itself against damage caused by alcohol. The first line of defence is a family of enzymes called aldehyde dehydrogenases (ALDH). These enzymes break down harmful acetaldehyde into acetate, which our cells can use as a source of energy.

In the study, when mice lacking the critical ALDH enzyme - ALDH2 - were given alcohol, it resulted in four times as much DNA damage in their cells compared to mice with the fully functioning ALDH2 enzyme. The second line of defence used by cells is a variety of DNA repair systems which, most of the time, allow them to fix and reverse different types of DNA damage. But they don't always work and some people carry mutations which mean their cells aren't able to carry out these repairs effectively.

The study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers. But it's important to remember that alcohol clearance and DNA repair systems are not perfect and alcohol can still cause cancer in different ways, even in people whose defence mechanisms are intact.
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Segluromet for treating type 2 diabetes

FDA Approves Segluromet (ertugliflozin and metformin hydrochloride) for Type 2 Diabetes. Segluromet is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are not adequately controlled on a regimen containing ertugliflozin or metformin, or in patients who are already treated with both ertugliflozin and metformin.

Segluromet is not recommended in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. The labeling for Segluromet contains a boxed warning for lactic acidosis. Segluromet is contraindicated in patients with severe renal impairment, end-stage renal disease or on dialysis, acute or chronic metabolic acidosis, including diabetic ketoacidosis, or a history of a serious hypersensitivity reaction to Segluromet, ertugliflozin or metformin hydrochloride.

Segluromet combines 2.5 mg or 7.5 mg of ertugliflozin with 500 mg or 1,000 mg of metformin hydrochloride. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g., carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment.

If metformin-associated lactic acidosis is suspected, immediately discontinue Segluromet (ertugliflozin and metformin hydrochloride) and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended. Ketoacidosis, a serious life-threatening condition requiring urgent hospitalization, has been reported in patients with type 1 and type 2 diabetes receiving SGLT2 inhibitors, including ertugliflozin. Some cases were fatal. Assess patients with signs and symptoms of metabolic acidosis for ketoacidosis, regardless of blood glucose level. If ketoacidosis is suspected, Segluromet should be discontinued, patient should be evaluated, and prompt treatment should be instituted.

Before initiating Segluromet, consider risk factors for ketoacidosis, including pancreatic insulin deficiency from any cause, caloric restriction, and alcohol abuse. In patients treated with Segluromet, consider monitoring for ketoacidosis and temporarily discontinuing Segluromet in clinical situations known to predispose to ketoacidosis (e.g., prolonged fasting due to acute illness or surgery).
Segluromet causes intravascular volume contraction and can cause renal impairment.

There have been reports of acute kidney injury, some requiring hospitalization and dialysis, in patients receiving SGLT2 inhibitors. Before initiating Segluromet, consider factors that may predispose patients to acute kidney injury. Consider temporarily discontinuing Segluromet in any setting of reduced oral intake or fluid losses; monitor patients for signs and symptoms of acute kidney injury. If acute kidney injury occurs, discontinue Segluromet promptly and institute treatment.
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Oral sex, alcohol and smoking can cause mouth cancer

Oral sex, smoking, drinking too much alcohol and a poor diet can increase the risk of mouth cancer. More than nine in ten mouth cancers are linked to lifestyle factors and the only way to curb this risk is by quitting or reducing habits such as smoking and drinking of alcohol.

Some types of oral cancer are linked to sexually transmitted human papilloma virus (HPV) infection in the mouth and throat. Being diagnosed with mouth cancer remains fairly unlikely but could happen to anybody so it is really important to know what to look for and be proactive in looking for the early warnings signs.

Lookout for mouth ulcers that do not heal within three weeks, red or white patches and unusual lumps and swellings. Places to check include the floor and roof of your mouth, inside of the cheeks, gums, tongue, lips, head and neck. If you notice any of these, please make an appointment with your dentist.
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Using mouthwash increases the risk of obesity and diabetes

Using mouthwash twice a day significantly raises the risk of obesity and developing type 2 diabetes, according to a new study. Swilling with the anti-bacterial fluid could be killing beneficial microbes which live in the mouth and protect against the conditions. People who used the product twice a day were around 55 percent more likely to develop diabetes or dangerous blood sugar spikes.

Popular mouthwash solutions include ingredients that kill good and bad bacterial. Most of these antibacterial ingredients in mouthwash are not selective- they do not target specific oral bacteria-instead, these ingredients can act on a broad range of bacteria.
Researchers looked at overweight people who were at risk of developing diabetes. Over the study period, around 17 per cent developed diabetes or pre-diabetes, but that rose to 20 per cent for those using mouthwash once a day, and 30 per cent for those using it in the morning and evening.

Helpful bacteria in the mouth can protect against obesity and diabetes, as it helps the body produce nitric oxide. This important molecule helps trillions of our cells to communicate with each other by transmitting signals throughout the entire body and regulates insulin levels and our metabolism. Commonly-used mouthwashes typically contain powerful bacteria-killing formulas including cetylpyridinium chloride, chlorhexidine, triclosan, alcohol, fluoride, peroxide and essential oils. However, the researchers warn killing off good helpful bacteria also makes room for harmful bacteria to thrive.
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Drinking of alcohol and metabolic factors increase the risk of liver disease

There is an increasing burden of liver disease and liver cancer. The metabolic syndrome and heavy alcohol consumption are associated with increased risks of liver disease, although only a minority of patients with early-stage liver disease (e.g. fatty liver) develop liver failure or liver cancer. Few general population studies have analyzed metabolic predictors of such severe liver complications.

Researchers studied which metabolic factors best predict severe liver complications. Their analysis included people without liver disease who participated in the Finnish population-based Health 2000 Study (2000-2001). The researchers analyzed follow-up data on liver-related hospital admissions, mortality, and liver cancer from national registers.

Some of the participants experienced a severe liver event during follow-up. Factors predictive of liver events were older age, female gender, alcohol use, diabetes, LDL cholesterol, and insulin resistance. Among individuals who consumed higher amounts of alcohol (average alcohol use ?210 g/week for men, ?140 g/week for women), diabetes was the only significant predictor.

Among those who consumed less or no alcohol, older age, alcohol use, smoking, abdominal obesity, LDL cholesterol, and insulin resistance were significant predictors. Alcoholic liver disease ALD and non-alcoholic liver disease NAFLD are considered separate entities, distinguished from each other by an arbitrary threshold of average alcohol intake.

This diagnostic approach assumes that alcohol intake does not affect the course of NAFLD and that the metabolic syndrome is the hallmark of NAFLD is not a factor in ALD. This study reveals that alcohol is a relevant risk factor even when alcohol consumption is within the limits currently used to separate NAFLD from ALD.

Liver disease should perhaps not be considered in terms of mutually exclusive entities of ALD and NAFLD, because in a large number of patients with liver disease, the effect of alcohol is difficult, and sometimes impossible, to separate from the effect of metabolic factors.

 Alcohol use and metabolic factors are taken into account at the same time in order to identify individuals with a high risk for severe liver complications. For a comprehensive liver-risk assessment, lipid abnormalities, abdominal obesity, insulin resistance, diabetes, and alcohol use should all be considered at the same time.
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Alcohol causes different cancers

The more alcohol you drink, the higher your risk of developing at least seven different types of cancers. Drinking small or moderate amounts of alcohol was associated with increased risks for esophogeal, mouth, voice box, liver, stomach, pancreas and breast cancers, and is responsible for more than five percent of cancers and cancer deaths worldwide.

The American Society of Clinical Oncology ASCO has never addressed the link between alcohol and cancer, but is now underscoring the importance of controlling the risk of alcohol consumption to reducing the risk of cancer. While the ASCO does suggest strategies for cutting back on drinking, it also advocates for temperate use of alcohol, rather than recommending give up drinking.

The Centres for Disease Control and Prevention CDC recommends that women should not have more than one drink a day or eight drinks a week. Men drink two drinks a day, or 14 a week. There has been some debate over whether alcohol or other compositions of various alcoholic beverages are cancer-causing. There is an associations between alcohol drinking and cancer risk. Alcohol does not affect each part of the body in the same carcinogenic way.

For head and neck and esophageal cancers, alcohol's breakdown product- acetaldehyde, which is an established carcinogen touches the tissues directly as drinker swallows an alcoholic drink and causes cancer. Liver cancer is caused by cirrhosis, which is caused by drinking. When cirrhosis develops, healthy liver cells are replaced by damaged scar tissue cells, which can become cancer cells. It interferes with the absorption of folate, which leads to development of colon cancer.

When a woman’s estrogen levels become abnormally high, the hormone puts her at higher risk for breast cancer. Alcohol has been shown to increase estrogen levels, thus putting women at greater risk of breast cancer. In fact, ASCO reports that women who drank even one drink of beer or wine which have significantly lower alcohol contents than liquors were five percent more likely to develop premenopausal breast cancer, and nine percent more likely to develop the cancer after menopause.
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Mental health condition surpreses the immune system

According to new research, depression increases the risk of an early death.
Men's risk of a premature death increases three-fold when suffering from the mental health condition, while women's risk is heightened by up to 50 percent.

Depression causes the release of stress hormones that suppress the immune system, putting sufferers at an increased risk of conditions such as cancer. People with the mental health condition may have unhealthy lifestyle habits, including a poor diet, inactivity and excessive alcohol intake.

Researchers analyzed more than 3000 adults between 1952 and 1967, 1968 and 1990, and 1991 and 2011. The study's participants' had an average age of 50 when the trial started. Results reveal depression increases the risk of an early death by up to three times. Men's risk increases three-fold, while women's peaks at 51 percent.

Depression is linked to the release of stress hormones that suppress the immune system, putting sufferers at increased risk of disorders including multiple sclerosis, arthritis and some. cancers. People with depression may also neglect their physical health through lifestyle habits such as a poor diet, inactivity, smoking and excessive alcohol intake. The mental health condition is more prevalent in women, however, past findings suggest men suffer the effects of it more as they are often less inclined to seek help.

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Obesity linked to different cancers

There is a link between obesity and different cancers, being obese or overweight was associated with cancer.
Some of the cancers linked with obesity include: brain cancer; multiple myeloma; cancer of the esophagus; postmenopausal breast cancer; cancers of the thyroid, gallbladder, stomach, liver, pancreas, kidney, ovaries, uterus and colon.

Of all cancers, 55 percent in women and 24 percent in men were associated with overweight and obesity. Blacks and whites had higher rates of weight-related cancer than other racial or ethnic groups. Black men and American Indian/Alaska Native men had higher rates of cancer than white men.

Except for colon cancer, cancers tied to overweight and obesity increased among those younger than 75 years.
Some other risk factors are smoking of cigarettes, drinking of alcohol, genetics,
sedentary lifestyle and poor nutrition.

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Alcohol affects levels of cholesterol through epigenetics

In an analysis of the epigenomes of people and mice, researchers discovered that drinking alcohol may induce changes to a cholesterol regulating gene. The findings suggest that these changes to the gene, PCSK9, may be responsible for some of the differences in how cholesterol is processed in people who drink alcohol, or may affect those taking a relatively new class of PCSK9 cholesterol-lowering drugs designed to reduce LDL cholesterol.

Chronic alcohol use can have detrimental effects on the liver and the cardiovascular system. Regulation of PCSK9 seems to correlate with this pattern and may be a significant underlying factor behind the variations in the relationship between cholesterol and cardiovascular disease when it comes to alcohol use. Researchers measure how drinking of alcohol can leads to changes in which genes are expressed.

They examined information from DNA chips- microarrays that can show which genes have chemical methyl groups added across the whole genome. These chips looked at about 500,000 methyl groups at a time. methylation affects the level of gene expression. The researchers used different sets of data: DNA from the brains of deceased people with documented alcohol dependence compared to healthy controls and DNA from blood samples of people who had documented alcohol dependence with healthy controls.

When the investigators cross-compared epigenetic data from the sets of data to find out what changes occurred in common in the two data sets and what changes did not, the common factor highlighted the gene PCSK9. The human liver samples from people with alcohol dependence who underwent a liver transplant and noticed a similar pattern: more methylation on PCSK9 and unexpectedly lower PCSK9 protein levels. In samples from people who abused alcohol, the researchers detected that PCSK9 gene expression was only a third of the level in people who didn't abuse alcohol.

Alcohol is metabolized by the liver and can cause liver damage if used in large amounts over long periods of time. In people, PCSK9 is found at its highest levels in liver, but is also found in other tissues, such as brain and blood. PCSK9 binds to the bad cholesterol receptors and blocks uptake and breakdown of bad cholesterol by cells, leading to accumulation in the bloodstream, where it presumably clogs arteries.
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Link between immune systems and drinking behaviour

Alcohol is the world's most commonly consumed drug, human body's circadian rhythms affect the reward signals we receive in the brain from drug-related behaviour, and the peak time for this reward occurs in the evening.

There is a link between the brain's immune system and the desire to drink alcohol in the evening. Researchers were able to switch off the impulse to drink alcohol in mice by giving them a drug that blocks a specific response from the immune system in the brain.

The researchers focused their attention on the immune receptor Toll-like receptor 4 (TLR4). They administered the drug (+)-Naltrexone, which is known to block TLR4, to mice. Naltrexo is used to reduce the amount and frequency of drinking.

They discovered reduction in alcohol drinking behaviour in mice that had been given (+)-Naltrexone, specifically at night when the reward for drug-related behaviour is high. Blocking a specific part of the brain's immune system substantially decrease the motivation of mice to drink alcohol in the evening.
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How to prevent colorectal cancer

The colon and rectum are parts of the digestive system, they make up the large intestine, most of the large intestine is made up of the colon.
Colorectal cancer is a cancer that starts in the colon or the rectum.

Physical activity protects against colon cancer. Colorectal cancer is one of the most common cancers, it is possible to prevent the cancer by eating healthy diet. Diet and lifestyle have a major role in colorectal cancer prevention

Foods containing fiber decreases the risk of this cancer. People who are more physically active have a lower risk of colon cancer compared to those who do very little physical activity.

Maintaining healthy weight, avoiding smoking and drinking of alcohol, proper exercise, limiting red and processed meat and eating more whole grains and fiber would lower the risk.

Eating whole grains daily, such as brown rice or whole-wheat bread, eating foods rich in vitamin C like oranges, strawberries and spinach can reduce colorectal cancer risk. Hot dogs, bacon and other processed meats consumed regularly increase the risk of the cancer.
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How belly fat increases the risk of cancer

Protein released from fat in the body can change a non-cancerous cell into a cancerous one. The lower layer of abdominal fat is responsible for releasing the protein and increasing tumour growth.

Obesity has been linked to several types of cancers including breast, colon, prostate, uterine and kidney. Abdominal obesity and levels of a protein called fibroblast growth factor-2 may be an indicator of cells becoming cancerous.

There are two layers of belly fat: the top layer, known as subcutaneous fat, lies right under the skin, the layer under that, called visceral fat is harmful and cancerous. High fat diet produce larger amounts of the fibroblast growth factor-2, FGF2, protein when compared to the subcutaneous fat.

FGF2 stimulated certain cells that were already vulnerable to the protein and caused them to grow into tumours. When fat secretions have more of the FGF2 protein, more of the cells formed cancerous tumours.

Humans can make a non-tumorigenic cell malignantly change into a tumorigenic cell by eating high fatty foods. Healthy lifestyle, eating fruits and vegetables, regular exercise, avoiding smoking and drinking of alcohol can prevents fat belly and reduce risk of developing cancer.
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Dementia risk factors

Dementia is caused when the brain is damaged by diseases like Alzheimer’s disease or a series of strokes. Healthy lifestyle can reduce the risk of developing dementia.

Older people suffering from Alzheimer's disease are prone to dementia disease because of irregular blood supply to the brain.

Drinking of alcohol regularly increases the risk of dementia. Alcohol can damage the brain directly as a neurotoxin and by reducing nutrients that get to the brain.

The accumulation of fats and cholesterol in the lining of arteries can prevents blood flow to the brain.

Poor management of diabetes can leads to too much sugar in the blood which can damage brain and different organs in the body.

Genetics- Having more than one family member that have the disease increases the risk of developing it.

High blood pressure affects the white matter regions of the brain, and this can leads to dementia.

Depression has been associated with mild mental impairment and cognitive function decline.

Smoking exposes brain to toxins and hinders blood flow, smokers are prone to diseases that reduce blood flow to the brain.
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Drinking increases risk of cancer

There is a link between drinking of alcohol and risk of digestive cancers.
Pancreatic, liver, gastric, bowel, and gullet cancers are the most common digestive cancers in the world.

Researchers discovered that those who drink more than one alcoholic drink per day are at the risk of digestive cancer.
Gullet cancer risk is increased by just a single drink per day.

Bowel cancer risk is increased by one to four drinks per day. Four or more drinks per day leads to higher risk of gastric, pancreatic, and liver cancers.

Combined drinking with smoking increase the risk of digestive cancers in the upper cavity. Alcoholic content of some beverages may increase cancer risk.
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Prenatal exposure to alcohol may affect children's IQ

Drinking of alcohol during pregnancy can cause fetal alcohol spectrum disorders in children, the alcohol molecule is very tiny and passes easily across the placenta from mother to fetus.

It may cause behavioral disorder and affects children's academic performance. The fetus experience delayed brain development in the womb because of alcohol.

Researchers examined children with prenatal alcohol exposure and children that were not exposed to alcohol on the cortical structure of their brains and academic performance.

The alcohol-exposed children performed worse than the other children in all academic areas.
 Their brain imaging showed several brain surface area clusters.

 The children without prenatal alcohol exposure showed good developmental pattern with good performance in all the academic tests.
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Facts about gullet cancer

The gullet, also known as oesophagus is the tube that carries food from mouth to stomach. Smoking, persistent acid reflux, drinking of alcohol, being overweight and obese can cause gullet cancer.

There are two types of gullet cancer – squamous cell cancer and adenocarcinoma. Eating foods low in fruit and vegetables can also increase the risk of developing gullet cancer.

If the disease is detected early it is possible to be cured. However, because the disease doesn’t usually cause symptoms until a later stage, it can be quite developed before it is detected.

The main symptom of gullet cancer are difficulty swallowing, heartburn, vomiting, weight loss, loss of appetite, chest pain, croaky voice, fatigue and dark poo.

Advanced stage of gullet cancer can spread to another part of the body.
Tumor that has not spread beyond the gullet can be treated with radiation therapy, chemotherapy, and surgery.

For squamous and adenocarcinoma cell cancer, chemotherapy, radiation therapy and chemoradiotherapy are recommended as the first treatment. Surgery may be used after checking the result of the chemoradiotherapy.

Bowel cancer can be prevented by avoiding smoking, eating fruits and vegetables, avoiding alcohol and seeking medical help when you have heart burn and when you experience any form of difficulty in swallowing food.
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