Symdeko for treating cystic fibrosis

The U.S. Food and Drug Administration (FDA) has approved Symdeko (ivacaftor/tezacaftor tablets and ivacaftor tablets) for treating the underlying cause of cystic fibrosis (CF) in people ages 12 and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or who have at least one mutation that is responsive to tezacaftor/ivacaftor.

Do not take Symdeko if you take certain medicines or herbal supplements such as: antibiotics such as rifampin (Rifamate, Rifater) or rifabutin (Mycobutin) seizure medicines such as phenobarbital, carbamazepine (Tegretol, Carbatrol, Equetro), or phenytoin (Dilantin, Phenytek)

Symdeko consists of 2 different tablets. The yellow tablet is marked with ‘V100’ and contains the medicines tezacaftor and ivacaftor. Take one yellow tablet in the morning. The light blue tablet is marked with ‘V150’ and contains the medicine ivacaftor. Take one light blue tablet in the evening. Take the yellow tablet and the light blue tablet about 12 hours apart.

Always take Symdeko with food that contains fat. Foods like egg, butter, peanut butter, cheese, pizza, and whole-milk dairy products such as whole milk, cheese, and yogurt. If you miss a dose and it is six hours or less from the time you usually take the yellow tablet in the morning or the light blue tablet in the evening, take the missed dose with food that contains fat as soon as you can. Then take your next dose at your usual time and it is more than six hours from the time you usually take the yellow tablet in the morning or the light blue tablet in the evening, do not take the missed dose. Take your next dose at the usual time with food that contains fat. Do not take more than usual dose to make up for a missed dose.

Symdeko can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how Symdeko affects you. Avoid food or drink that contains grapefruit or Seville oranges while you are taking Symdeko. It can cause serious side effects, including: high liver enzymes in the blood.

Call your doctor right away if you have any of the following symptoms of liver problems:pain or discomfort in the upper right stomach (abdominal) area, yellowing of your skin or the white part of your eyes, loss of appetite, nausea or vomiting, dark amber-colored urine. Abnormality of the eye lens (cataract) in some children and adolescents treated with Symdeko or treated with ivacaftor alone. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment to look for cataracts. The most common side effects include: headache, nausea, sinus congestion and dizziness.
          haleplushearty.blogspot.com

How to cure a burned mouth

Burns on the tongue heal faster than on the roof of the mouth, since the tongue has the most blood vessel supply in the entire body.

However, the pain can be searing since the skin here is more sensitive than other parts of the body, and it doesn't have any fat between the skin and the bones. As a result, it usually lingers two to three days.

Burned mouth can be healed quickly by sticking to a soft diet like yogurt and sushi, avoiding spice,noodles,soup, iced drink and hot foods eat lukewarm food - room temperature.

Coffee, wine and soda should all be off the menu for days. These foods are acidic, they will irritate skin as it's healing, potentially delaying the healing process.

Bacteria in an open wound can lead to infection and prevent healing. After a burn, brush your teeth thoroughly, use mouthwash, and drink plenty of water to wash out any built-up food or bacteria from your mouth.
          haleplushearty.blogspot.com

Alzheimer's gene and poor diet increase the risk of developing the disease

Alzheimer’s gene and diet rich in fat and sugar can increase the risk of developing the disease.
ApoE4 gene that affects memory is the major cause of Alzheimer's disease.

Genes, diet, environment and lifestyle determine risk of developing any disease including Alzheimer's disease.
ApoE4 and ApoE3 are two variants of a gene that codes for a protein, apolipoprotein E, which combine fat and cholesterol and take them to the body’s lymphatic and circulatory systems and to the brain.

The ApoE4 causes an inflammation, Alzheimer’s diseases and cardiovascular disease while ApoE3 does not increase risk of the disease. ApoE4 is present in about fifteen percent of people. Alzheimer’s affects more women than men.

Fatty acids like palmitic acid can cause inflammation in the brain because they can go into the brain and affect glia. Glia is responsible for immune response in the brain, poor diet can make it less effective in protecting the brain.

          haleplushearty.blogspot.com

High fat diet reduces symptoms of Crohn's disease

High fat diet changes gut bacteria, reduces inflammation and symptoms of Crohn's disease. Crohn's disease is a type of inflammatory bowel syndrome that causes intestinal swelling, cramping and diarrhea.

 Diet of plant-based fats, reduced bacterial diversity in mice with Crohn's-like disease. Researchers fed mice with different fat diet, mice fed fatty diets had up to thirty percent fewer kinds of gut bacteria as those fed a normal diet.

 Crohn's patient can reduce their gut inflammation by adding good fat to their diet in moderation to prevent inflammation bowel syndrome.

All the good fats may have different results in different patients. Patients can start by trying different fat diet to discover the one that is good for their gut bacteria.

      haleplushearty.blogspot.com

       

How to identify obesity

Obesity is largely calculated using body mass index (BMI). However, new research may have discovered a better way to measure it.

BMI is based on the healthy weight for a person’s height, but experts have long pointed out its limitations.

Researchers said calculating a person’s waist-to-height ratio (WHtR) is more accurate and efficient.

It could be used, in particular, to identify whether someone is obese, and therefore at risk of several other health problems.

This new method examines whole-body fat percentage and visceral adipose tissue mass - the fat stored around the abdominal region where most of the internal organs are.

            haleplushearty.blogspot.com

Warm planet may increase diabetes

Global warming is increase in temperature of the earth surface, warm temperature will deactivate the use of brown fat in the body.

Diabetes occurs when the amount of sugar in the blood is too much because the body cannot use it properly.

If the global warming continues it may increase diabetes by making brown cell inactive for a long period of time.

Brown fat is very active in winter, when the temperature is cold. People with type 2 diabetes can be expose to cold regularly to improve the use of insulin. It can also leads to production of new brown fat cells in the body.

Obesity may cause liver disease

Obesity is a condition of having excess fat in the body that is having negative effect on the body, you are obese if your body mass index BMI is or greater than 30.

Excess food intake and lack of physical activity can cause obesity, Obesity is one of the major causes of liver disease.

Excess weight can cause non - alcoholic fatty liver disease NAFLD, this is a condition of building - up of fat within liver cells.

Recent study provides link between obesity and liver disease, being overweight or obese can cause NAFLD, it is good to work on weight reduction from early age to prevent liver disease later in life.

Intensive medical attention can reverse type 2 diabetes

Diabetes mellitus DM is a group of diseases associated with high blood sugar, common symptoms are: increased thirst, increase hunger and frequent urination.

When pancreas failed to produce enough insulin - type 1 or when body failed to respond to insulin properly - type 2 are the common types of diabetes.

Correct combination of medications, insulin and lifestyle therapies for three to four months can reverse type 2 diabetes according to latest study on diabetes.

Bariatric surgery is not the only solution to type 2 diabetes, following standard lifestyle advice from your Doctor, will leads to achieving normal glucose level with the aid of medications.

The oral medication, insulin and lifestyle therapies will give your pancreas rest and decrease fat stores in your body; this will improve insulin production and make your pancreas active.