Vitamin D supplements could ease irritable bowel syndrome

Vitamin D supplements could ease painful Irritable Bowel Syndrome IBS symptoms. Scientists from the University's Department of Oncology and Metabolism reviewed and integrated all available research on vitamin D and IBS. The study showed a high prevalence of vitamin D deficiency in IBS patients. They also assessed the possible benefits of vitamin D supplements on IBS symptoms. Their findings suggested supplements may help to ease symptoms which can include abdominal pain, bloating, diarrhea and constipation. Vitamin D was shown to have the most benefit on quality of life in IBS.

People with IBS should have their vitamin D levels tested and a large majority of them would benefit from supplements. IBS is a poor condition which impacts severely on the quality of life of sufferers. There is no single known cause and no cure. IBS is a debilitating functional disorder of the gastrointestinal (GI) tract. Little is known about why and how the condition develops, although it is known that diet and stress can make symptoms worse.

Vitamin D is essential for general wellbeing, including bone health, immune function, mental health as well as gut health. Vitamin D inadequacy can be remedied relatively easily with supplements if diagnosed. Low vitamin D status has already been associated with the risk of colorectal cancer and has been implicated in inflammatory bowel disease.
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Valsartan for treating high blood pressure

Valsartan is an angiotensin II receptor antagonist. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. It is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. Valsartan is also used in adults to treat heart failure, and to lower the risk of death after a heart attack. It is sometimes given together with other blood pressure medications.

If you have diabetes, do not use valsartan together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna). Before taking this medicine. Do not use valsartan if you are allergic to it. You may take valsartan with or without food. Take the medicine at the same time each day. If a child taking valsartan cannot swallow a capsule whole, your pharmacist can mix the medicine into a liquid. Shake this liquid well just before you measure a dose.

Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. You may have very low blood pressure while taking valsartan. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Drinking alcohol can further lower your blood pressure and may increase certain side effects of valsartan. Do not use potassium supplements or salt substitutes while you are taking valsartan, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, valsartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
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Mepsevii for treating inherited metabolic condition

The U.S. Food and Drug Administration has approved Mepsevii (vestronidase alfa-vjbk) to treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome. MPS VII is an extremely rare, progressive condition that affects most tissues and organs.

MPS VII is an inherited, rare genetic condition and impacts less than 150 patients worldwide. The features of MPS VII vary widely from patient to patient, but most patients have various skeletal abnormalities that become more pronounced with age, including short stature. Affected individuals can also develop heart valve abnormalities, enlarged liver and spleen, and narrowed airways which can lead to lung infections and trouble breathing.

The life expectancy of individuals with MPS VII depends on the severity of symptoms. Some affected individuals do not survive infancy, while others may live into adolescence or adulthood. Heart disease and airway obstruction are major causes of death in people with MPS VII. Affected individuals may have developmental delay and progressive intellectual disability.

The safety and efficacy of Mepsevii were established in clinical trial and expanded access protocols enrolling a total of 23 patients ranging from 5 months to 25 years of age. Patients received treatment with Mepsevii at doses up to 4 mg/kg once every two weeks for up to 164 weeks. Efficacy was primarily assessed via the six-minute walk test in ten patients who could perform the test. After 24 weeks of treatment, the mean difference in distance walked relative to placebo was 18 meters.

Additional follow-up for up to 120 weeks suggested continued improvement in three patients and stabilization in the others. Two patients in the Mepsevii development program experienced marked improvement in pulmonary function. Overall, the results observed would not have been anticipated in the absence of treatment. The most common side effects after treatment with Mepsevii include infusion site reactions, diarrhea, rash and anaphylaxis.
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Benznidazole drug for treating American trypanosomiasis

Benznidazole belongs to a group of medicines called antiprotozoals. It is used to treat an infection called American trypanosomiasis.
Benznidazole works by killing the protozoa.

Take the medicine with meals, after breakfast and after supper, to decrease the chance of stomach upset. If you get an upset stomach (diarrhea, nausea, stomach pain, or vomiting) and it continues, check with your doctor.

Although rare, Benznidazole can lower the number of white blood cells in the blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting.

Common side effects of this drug are-
Convulsions (seizures); numbness, tingling pain, or weakness in hands or feet; reddish discoloration of skin,
fever or chills; pinpoint red spots on skin; skin rash; sore throat; unusual bleeding or bruising.

Other side effects are- abdominal or stomach pain; diarrhea; nausea; vomiting, confusion; dizziness; headache; restlessness; temporary loss of memory; trouble in sleeping; difficulty concentrating; unusual tiredness and fatigue.
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Duzallo drugs for treating gout

Duzallo is a prescription medicine that contains two medicines, a URAT1 inhibitor called lesinurad and a xanthine oxidase inhibitor called allopurinol. It is used to lower uric acid levels in the blood of people with gout.

Active ingredients are lesinurad and allopurinol. Inactive ingredients: crospovidone, hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, iron oxide red, iron oxide yellow, titanium dioxide, and triacetin.

Duzallo can cause serious side effects, like kidney problems. People taking Duzallo may have kidney problems such as a sudden decrease in kidney function (acute kidney failure).
Duzallo can affect bone marrow and cause low red blood cells, white blood cells and platelets.

Other side effects are: skin rash; blistering of the skin, mouth, nose, and genitals, painful red or purple skin that looks burned and peels off, joint pain; swollen glands red, painful, watery eyes; persistent itching; hives, fever, loss of appetite, weight loss, fatigue, nausea, heartburn and diarrhea
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Idhifa drug for treatment of acute myeloid leukemia

The U.S. Food and Drug Administration has approved Idhifa (enasidenib), an isocitrate dehydrogenase-2 inhibitor for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an FDA-approved test.

Idhifa is a prescription medicine used to treat people with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation whose disease has come back or has not improved after first treatment.

Enasidenib is an active ingredient in Idhifa while the inactive ingredients are: colloidal silicon dioxide, hydroxypropyl cellulose, hypromellose acetate succinate, iron oxide yellow, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, sodium lauryl sulfate, sodium starch glycolate, talc and titanium dioxide

The drug may cause serious side effects like:nausea, vomiting, diarrhea, jaundice and lack of appetite.
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Vosevi drug for hepatitis treatment

Hepatitis C is a viral infection that can cause inflammation and serious damage to the liver. The virus is spread through human contact with infected blood.

The U.S. Food and Drug Administration (FDA) has approved Vosevi (sofosbuvir 400 mg/velpatasvir 100 mg/voxilaprevir 100 mg) tablets, a single-tablet regimen for the treatment of adults with chronic hepatitis C virus (HCV).

Vosevi is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis who have:
genotype 1, 2, 3, 4, 5, or 6 infection and have previously been treated with an HCV regimen containing an NS5A inhibitor.

Do not combine Vosevi with any medicines that contain rifampin (Rifater, Rifamate, Rimactane, Rifadin).
Before taking Vosevi

The drug can cause serious side effects, like: Hepatitis B virus (HBV) reactivation, slow heart rate, fainting,
dizziness, shortness of breath, chest pains, confusion, memory problems, headache, tiredness, diarrhea, and nausea.
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Nerlynx drug for early breast cancer treatment

Breast cancer starts when cells in the breast begin to grow out of control. The cancers can start from different parts of the breast. It can start from the ducts that carry milk to the nipple or in the glands that make breast milk.

The U.S. Food and Drug Administration FDA has approved Nerlynx a once-daily oral tyrosine kinase inhibitor for the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer.

Nerlynx is a prescription medicine used to treat adults who have early-stage breast cancer, which is HER2-positive and has previously been treated with the medicine trastuzumab.

Nerlynx may cause serious side effects like diarrhea, liver problems, fatigue,
vomiting, fever, rash, right upper abdominal pain, weight loss and urinary tract infection UTI.

Pregnant women, nursing mother and women planning to get pregnant can not use Nerlynx.
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Tremfya drug for treating plaque psoriasis

Plaque psoriasis is an inherited systemic inflammatory disease of immune dysfunction that causes plaques of elevated, scaling and inflamed skin.

The plaques are common on the scalp, elbows, and knees. Genetic and environmental factors are the most causes of the disease.

The U.S. Food and Drug Administration FDAhas approved Tremfya (guselkumab), an interleukin-23 blocker for the treatment of adult patients with moderate-to-severe plaque psoriasis.

 Tremfya is a medicine that may lower the ability of immune system to fight infections and may increase risk of infections.

Tremfya is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills.

Common side effects of this drug are:
upper respiratory infections, joint pain,
fungal skin infections, headache and diarrhea.
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Eating raw spinach can cause kidney stones

Spinach is a good source of dietary fiber, raw spinach has oxalic acid, it can react with minerals in our intestines to form calcium oxalate precipitation which can cause kidney stones.

Other foods that have high oxalic acid are swiss chard, beetroot, almonds, cashew nut, buckwheat, tea, coffee, chocolate and parsley.

Eating raw spinach can cause diarrhea and abdominal pain. Excess consumption of raw spinach can make it difficult for your body to absorb required amount of iron from ingested foods.

People who are genetically predisposed to kidney stone formation must be very careful when consuming raw spinach,
cooking or steaming of spinach can destroy oxalic acid in it.
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High fat diet reduces symptoms of Crohn's disease

High fat diet changes gut bacteria, reduces inflammation and symptoms of Crohn's disease. Crohn's disease is a type of inflammatory bowel syndrome that causes intestinal swelling, cramping and diarrhea.

 Diet of plant-based fats, reduced bacterial diversity in mice with Crohn's-like disease. Researchers fed mice with different fat diet, mice fed fatty diets had up to thirty percent fewer kinds of gut bacteria as those fed a normal diet.

 Crohn's patient can reduce their gut inflammation by adding good fat to their diet in moderation to prevent inflammation bowel syndrome.

All the good fats may have different results in different patients. Patients can start by trying different fat diet to discover the one that is good for their gut bacteria.

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