Clenpiq for Colonoscopy Prep

Food and Drug Administration FDA has granted approval of Clenpiq (sodium picosulfate, magnesium oxide, and anhydrous citric acid) oral solution for cleansing of the colon in adults undergoing a colonoscopy. Colonoscopies can reduce the incidence of colorectal cancer and deaths associated with this disease. Successful bowel prep is critical for gastroenterologists to clearly see the inside of the colon during a colonoscopy.

The sheer volume of a prescribed bowel prep solution can be a barrier for some patients to adequately complete their prep regimen, leading to suboptimal visualization of the colon, A ready-to-drink, low volume colonoscopy prep in a pre-mixed oral solution is an excellent start to prepare patients for this important procedure to detect and prevent colorectal cancer.

Clenpiq is a ready-to-drink cranberry-flavored, dual-acting, combination of sodium picosulfate, a stimulant laxative, and magnesium oxide and anhydrous citric acid, which forms magnesium citrate, an osmotic laxative indicated for cleansing of the colon as a preparation for colonoscopy in adults.

Clenpiq is contraindicated in the following conditions: patients with severe renal impairment (creatnine clearance less than 30mL/minute), gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, gastric retention, or in patients with a known hypersensitivity to any of the ingredients in Clenpiq.

Patients should be advised to hydrate adequately (before, during and after use of Clenpiq), and post-colonoscopy lab tests should be considered if a patient develops significant vomiting or signs of dehydration, including orthostatic hypotension, after taking Clenpiq. Patients with electrolyte abnormalities should have them corrected before treatment. The most common adverse reactions in those trials were nausea, headache, and vomiting.
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Cadmium increases the risk of cancer of the womb

Cadmium is a heavy metal that is produced during the smelting of other metals like zinc, lead and copper.
Cadmium in kidneys and liver of animals, shellfish, mushrooms and cigarettes increases a woman's risk of womb cancer.

Cadmium is a chemical that mimic the effects of estrogen in the body. It disrupts the hormonal balance and encourage rapid cell division. Foods rich in cadmium must be eaten in moderation.

Endometrial cancer known as cancer of the womb, has been associated with estrogen exposure because cadmium mimics estrogen, it may lead to an increased growth of the endometrium, contributing to an increased risk of endometrial cancer.

It is common in older women but can occur at any age in matured women. Common symptoms are abnormal bleeding from the vagina, heavier periods, vagina bleeding in between normal periods, pain in the lower abdomen and pain during sex, loss of appetite, tiredness and nausea.
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Idhifa drug for treatment of acute myeloid leukemia

The U.S. Food and Drug Administration has approved Idhifa (enasidenib), an isocitrate dehydrogenase-2 inhibitor for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an FDA-approved test.

Idhifa is a prescription medicine used to treat people with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation whose disease has come back or has not improved after first treatment.

Enasidenib is an active ingredient in Idhifa while the inactive ingredients are: colloidal silicon dioxide, hydroxypropyl cellulose, hypromellose acetate succinate, iron oxide yellow, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, sodium lauryl sulfate, sodium starch glycolate, talc and titanium dioxide

The drug may cause serious side effects like:nausea, vomiting, diarrhea, jaundice and lack of appetite.
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Vosevi drug for hepatitis treatment

Hepatitis C is a viral infection that can cause inflammation and serious damage to the liver. The virus is spread through human contact with infected blood.

The U.S. Food and Drug Administration (FDA) has approved Vosevi (sofosbuvir 400 mg/velpatasvir 100 mg/voxilaprevir 100 mg) tablets, a single-tablet regimen for the treatment of adults with chronic hepatitis C virus (HCV).

Vosevi is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis who have:
genotype 1, 2, 3, 4, 5, or 6 infection and have previously been treated with an HCV regimen containing an NS5A inhibitor.

Do not combine Vosevi with any medicines that contain rifampin (Rifater, Rifamate, Rimactane, Rifadin).
Before taking Vosevi

The drug can cause serious side effects, like: Hepatitis B virus (HBV) reactivation, slow heart rate, fainting,
dizziness, shortness of breath, chest pains, confusion, memory problems, headache, tiredness, diarrhea, and nausea.
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Link between migraines and body mass index

Migraines are severe, painful headache disorder, common symptoms are: nausea, vomiting, sensitivity to light, sound or smell.

Physician suggested stress management, relaxation, regular exercise and eating regularly to manage symptoms of migraines.

Researchers examined 290,000 people and discovered that obese people had a 27 percent higher risk of migraine than the people with normal weight while underweight had 13 percent higher risk of migraine compared with  normal weight people.

According to Dr. Lee Peterlin of Johns Hopkins University School of medicine, a member of the American Academy of Neurology said age and sex were key variables in the correlation between migraine risk and body mass index.

Obesity and being underweight are possible risk factors for migraine, taking this into consideration will enhance effective treatment of migraine.