Symdeko for treating cystic fibrosis

The U.S. Food and Drug Administration (FDA) has approved Symdeko (ivacaftor/tezacaftor tablets and ivacaftor tablets) for treating the underlying cause of cystic fibrosis (CF) in people ages 12 and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or who have at least one mutation that is responsive to tezacaftor/ivacaftor.

Do not take Symdeko if you take certain medicines or herbal supplements such as: antibiotics such as rifampin (Rifamate, Rifater) or rifabutin (Mycobutin) seizure medicines such as phenobarbital, carbamazepine (Tegretol, Carbatrol, Equetro), or phenytoin (Dilantin, Phenytek)

Symdeko consists of 2 different tablets. The yellow tablet is marked with ‘V100’ and contains the medicines tezacaftor and ivacaftor. Take one yellow tablet in the morning. The light blue tablet is marked with ‘V150’ and contains the medicine ivacaftor. Take one light blue tablet in the evening. Take the yellow tablet and the light blue tablet about 12 hours apart.

Always take Symdeko with food that contains fat. Foods like egg, butter, peanut butter, cheese, pizza, and whole-milk dairy products such as whole milk, cheese, and yogurt. If you miss a dose and it is six hours or less from the time you usually take the yellow tablet in the morning or the light blue tablet in the evening, take the missed dose with food that contains fat as soon as you can. Then take your next dose at your usual time and it is more than six hours from the time you usually take the yellow tablet in the morning or the light blue tablet in the evening, do not take the missed dose. Take your next dose at the usual time with food that contains fat. Do not take more than usual dose to make up for a missed dose.

Symdeko can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how Symdeko affects you. Avoid food or drink that contains grapefruit or Seville oranges while you are taking Symdeko. It can cause serious side effects, including: high liver enzymes in the blood.

Call your doctor right away if you have any of the following symptoms of liver problems:pain or discomfort in the upper right stomach (abdominal) area, yellowing of your skin or the white part of your eyes, loss of appetite, nausea or vomiting, dark amber-colored urine. Abnormality of the eye lens (cataract) in some children and adolescents treated with Symdeko or treated with ivacaftor alone. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment to look for cataracts. The most common side effects include: headache, nausea, sinus congestion and dizziness.
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Spotting eating disorders

Eating disorders are conditions that negatively impact human health, emotions and ability to function in important areas of life. Common eating disorders are : anorexia, bulimia or binge-eating.

Anorexia: Weight loss is one of the most obvious signs of anorexia. But even when they're drastically underweight, anorexics may still think they're too heavy. Some people with anorexia try to hide their thinness beneath layers of baggy clothes.

They may eat just one small meal, always say they aren't hungry or avoid starchy foods or carbohydrates. They may also avoid social situations, and exercise excessively. Anorexia can lead to dizziness, concentration problems, pale or dry skin, trouble sleeping, weak muscles and thin hair. Girls and women with anorexia may also stop menstruating.

Bulimia: People with bulimia are always dieting and hiding food. They may eat to the point of discomfort but only when no one is watching. After overeating, people with bulimia force themselves to throw up, usually by putting their fingers down their throat. Marks on the back of their hands may indicate bulimia. Routinely using laxatives or going to the bathroom right after eating are also signs of bulimia.

Binge-eating: Binge-eaters consume large amounts of food very quickly, stopping only when they are uncomfortably full. When bingeing, they tend to feel out of control. Binge-eating is hard to identify because it may happen only occasionally. This behavior can continue for a long period of time before notice.
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Benznidazole drug for treating American trypanosomiasis

Benznidazole belongs to a group of medicines called antiprotozoals. It is used to treat an infection called American trypanosomiasis.
Benznidazole works by killing the protozoa.

Take the medicine with meals, after breakfast and after supper, to decrease the chance of stomach upset. If you get an upset stomach (diarrhea, nausea, stomach pain, or vomiting) and it continues, check with your doctor.

Although rare, Benznidazole can lower the number of white blood cells in the blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting.

Common side effects of this drug are-
Convulsions (seizures); numbness, tingling pain, or weakness in hands or feet; reddish discoloration of skin,
fever or chills; pinpoint red spots on skin; skin rash; sore throat; unusual bleeding or bruising.

Other side effects are- abdominal or stomach pain; diarrhea; nausea; vomiting, confusion; dizziness; headache; restlessness; temporary loss of memory; trouble in sleeping; difficulty concentrating; unusual tiredness and fatigue.
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Carospir for treating hypokalemia

Carospir (spironolactone) is a potassium-sparing diuretic water pill that prevents body from absorbing too much salt and keeps potassium levels from getting too low.

Spironolactone is used to diagnose or treat a condition of too much aldosterone in the body. Aldosterone is a hormone produced by adrenal glands to regulate the salt and water balance in the body.

Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder known as nephrotic syndrome.

 Spironolactone is used for treating or preventing low potassium levels in the blood. Avoid  spironolactone if you are allergic to the drug, have kidney disease, or if you are unable to urinate.

Common side effects are: mild nausea, vomiting, diarrhea, breast swelling or tenderness, dizziness, headache, mild drowsiness, leg cramps and impotence hives, difficulty breathing, swelling of face, lips, tongue, or throat.
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Vosevi drug for hepatitis treatment

Hepatitis C is a viral infection that can cause inflammation and serious damage to the liver. The virus is spread through human contact with infected blood.

The U.S. Food and Drug Administration (FDA) has approved Vosevi (sofosbuvir 400 mg/velpatasvir 100 mg/voxilaprevir 100 mg) tablets, a single-tablet regimen for the treatment of adults with chronic hepatitis C virus (HCV).

Vosevi is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis who have:
genotype 1, 2, 3, 4, 5, or 6 infection and have previously been treated with an HCV regimen containing an NS5A inhibitor.

Do not combine Vosevi with any medicines that contain rifampin (Rifater, Rifamate, Rimactane, Rifadin).
Before taking Vosevi

The drug can cause serious side effects, like: Hepatitis B virus (HBV) reactivation, slow heart rate, fainting,
dizziness, shortness of breath, chest pains, confusion, memory problems, headache, tiredness, diarrhea, and nausea.
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Latest facts about dementia

Dementia is decline of the brain and its abilities, causing memory loss and slower thinking.

It’s currently incurable, but early diagnosis usually means less impact on sufferers’ lives and better support provided to them.

People who explained drops in their
blood pressure, causing dizziness when they stand, may have an increased risk of developing dementia.

Speaking another language could prevent dementia. Being bilingual delay
dementia by making the brain more resilient.

A component of turmeric - curcumin - was discovered to potentially prevent age-related cognitive decline.

Consuming more omega 3 a natural fatty acid found in rich levels on oily fish, eggs and seeds have anti-inflammatory effects on the brain.

Surviving a stroke places you at an increased risk of developing dementia.



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