Immune system imbalanced due to overly-active cells or cells that suppress its function can cause different diseases. Manipulating the function of T cells, could restore the immune system's balance and create new treatments for any diseases.
Pro-inflammatory cells that boost the immune system can be rearrange into anti-inflammatory cells that suppress disease. Effector T cells activate the immune system to defend human body against different pathogens while regulatory T cells control the immune system and prevent it from attacking healthy parts of its cells.
This rearrangement can be used in the treatment of autoimmune diseases and immuno-oncology therapies. The use of molecule drug that can rearrange effector T cells into regulatory T cells is very important for strengthening immune systems. This metabolic mechanism changes one cell type into another.
In autoimmune disease, effector T cells are activated and cause damage to the body. Changing these cells into regulatory T cells could reduce the hyperactivity and return balance to the immune system. This rearrangement could improve therapies using stem cells, promotes immune tolerance and prevents the body from rejecting newly-transplanted cells.
Some cancers control regulatory T cells to suppress the immune system and allowing tumors to grow without detection. This process can activate the immune system, recognize cancer cells and attack them.
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