Triclocarbon in soaps can affects fetus lipid metabolism

Lipids are naturally occurring molecules that includes fats, waxes, fat-soluble vitamins, monoglycerides, diglycerides and triglycerides. Lipids stored energy and signal and act as structural components of cell membranes.

Triclocarban TCC is an antibacterial agent in daily care products like soaps and toothpaste. Exposure to TCC through the use of daily care products can affect fetus proper formation. This can cause irreversible changes to the developing fetuses.

 Researchers injected TCC laced with carbon-14 to trace how the contaminant distributed in organ systems of female mice and exposed offspring.
 Using accelerator mass spectrometry AMS. AMS fills a special niche in the biomedical field because it can measure very low concentrations of compounds with extreme accuracy and track bio-distribution and excretion over long periods of time.

This showed that TCC effectively transfer from mother to offspring through placenta and breastfeeding.
 Exposure to TCC during development may pose a health risk to the developing fetuses because they are more sensitive to alterations in hormone levels, which may leads to an irrelevant changes. TCC-related compounds were detected in the tissues of offspring with significantly higher concentrations in the brain, heart and fat.

Quantitative real-time polymerase chain reaction qPCR was used in the study to examine changes in gene expression in liver and adipose tissue in the exposed offspring. The results showed alterations in genes involved in lipid metabolism in exposed female offspring were consistent with the observed increase in fat weights and hepatic triglycerides. Exposed offspring were heavier in weight than unexposed.
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