Low-calorie diet and eating less keeps the body younger. Body's biological clock change as a result of physiological aging, the clock controlled circuit that directly connects to the process of aging is based on efficient metabolism of energy within cells.
Energy is metabolized within cells under precise circadian controls.
The researchers found that the 24-hour cycle in the circadian-controlled metabolic system of older mice remained the same, but there were notable changes in the circadian mechanism that turns genes on and off based upon the cells' energy usage.
Older cells processed energy inefficiently. Caloric restriction works by sprucing up the biological clock. According to scientists, low-calorie diet conserved most of the rhythmic functions in young people.
The low-calorie diet greatly contributes to preventing the effects of physiological aging. Keeping the rhythm of stem cells young is important because these cells renew and preserve day-night cycles in tissue.
Eating less prevent tissue aging, therefore, it prevents stem cells from reprogramming their circadian activities. Calorie restriction influences the body's circadian rhythms involvement with the aging process in cells. Circadian rhythm-metabolism link circadian enzyme protein called SIRT1 works.
SIRT1 senses energy levels in cells; its activity is modulated by how many nutrients a cell is consuming. It helps cells resist oxidative and radiation-induced stress. SIRT1 has also been linked to the inflammatory response, diabetes and aging.
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