Pain signals travel from the injured area to spinal cord and to the brain, chronic pain is different from typical pain. Chronic pain is an experience of continuous pain even after an injury heals and it may last for weeks. The pain may be sharp or dull, causing a burning or aching sensation in the affected areas. It may be steady or intermittent.
Chronic pain occurred when nerves in the central nervous system are damaged, it can occur in any part of the body. Some of the most common types of chronic pain are: headache, post-trauma pain, lower back pain, arthritis pain, neurogenic pain and psychogenic pain.
The synthetic compound, called UKH-1114, is effective at relieving neuropathic pain in injured mice as a drug widely used for pain relief called gabapentin, but it works at a much lower dose, with longer duration of action.
UKH1114 binds to a receptor on cells throughout the central nervous system called the sigma 2 receptor. Researchers tested UKH-1114 on mice with nerve damage and found that it alleviated pain at a much lower dose and was effective much longer.
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