Moles are growths on the skin that are usually brown or black. They can appear in groups or alone in any parts of the body. As we get older, some moles can change in colour or disappear while others may remain the same.
Moles occur when cells in the skin grow in a cluster instead of being spread throughout the skin. Melanoma is a type of skin cancer, it developed when unrepaired DNA damage skin cells.
Melanomas often resemble moles; some develop from moles. Melanomas can develop from a naevus, but most moles will never become a melanoma.
Dermatologists examined some moles and discovered some had a mutation on the gene known as BRAF, and the remaining samples had a mutation on the NRAS gene.
When either of these genes are mutated it activates the signalling pathway known as MAPK, which is commonly active in melanomas.
Additional genomic events need to occur before a mole becomes malignant. People with a high number of moles, and other risk like fair skin or light coloured hair or eyes, should continue to keep appointment with their dermatologist for regular skin examination.
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