Death of therapy sensitive cancer cells leads to the release of a killer peptide that can eliminate therapy resistant cells. Tumor relapse is a problem after cancer treatment, because primary tumor cells always contain therapy resistance cancer cells that continue to proliferate after the therapy-sensitive cells have been removed.
A Par-4 amino-terminal fragment PAF that is released by diverse therapy-sensitive cancer cells after therapy-induced cleavage of the tumor suppressor Par-4 protein. PAF caused death in cancer cells resistant to therapy and prevented metastatic tumor growth.
Naturally generated PAF could potentially be harnessed to target cancer cells to overcome metastasis and therapy resistance in tumors. The PAF entered only cancer cells, not normal cells, keeping healthy tissue alive.
The use of sensitive cells in the tumor to release this peptide to destroy the resistant cells will be a good method in killing cancer cells. PAF development is a good method against therapy resistant tumor metastasis because there is no other treatment option for it.
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