Vitamin D enhances healing of burns

Patients with severe burns who have higher levels of vitamin D recover more successfully than those with lower levels. Despite improvements in burn care many patients are still at risk of poor recovery. Complications can range from delayed wound healing through to infections. Patients with severe burns are at high risk of infection that may lead to life-threatening sepsis.

Vitamin D is known to have antibacterial actions that may combat infection and therefore aid in wound healing of burn patients. In order to investigate the role of vitamin D in recovery from burn injuries, researchers assessed the recovery progress, over one year, in patients with severe burns and correlated this with their vitamin D levels.

The study found that patients with higher levels of vitamin D had a better prognosis, with improved wound healing, fewer complications and less scarring. The data also showed that burns patients tend to have lower levels of vitamin D. These data suggest that vitamin D supplementation immediately following burn injury may have potent health benefits to the patient, including enhanced antimicrobial activity to prevent infection, and improved wound healing.

Major burn injury severely reduces vitamin D levels and adding this vitamin back may be a simple, safe and cost-effective way to improve outcomes for burns patients. The effectiveness of vitamin D supplementation to improve outcomes in burn patients would need to be verified in clinical trials.

Low vitamin D levels were associated with worse outcomes in burn patients including life threatening infections, mortality and delayed wound healing . It was also associated with worse scarring but vitamin D levels can improve the healing process.
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Triclocarbon in soaps can affects fetus lipid metabolism

Lipids are naturally occurring molecules that includes fats, waxes, fat-soluble vitamins, monoglycerides, diglycerides and triglycerides. Lipids stored energy and signal and act as structural components of cell membranes.

Triclocarban TCC is an antibacterial agent in daily care products like soaps and toothpaste. Exposure to TCC through the use of daily care products can affect fetus proper formation. This can cause irreversible changes to the developing fetuses.

 Researchers injected TCC laced with carbon-14 to trace how the contaminant distributed in organ systems of female mice and exposed offspring.
 Using accelerator mass spectrometry AMS. AMS fills a special niche in the biomedical field because it can measure very low concentrations of compounds with extreme accuracy and track bio-distribution and excretion over long periods of time.

This showed that TCC effectively transfer from mother to offspring through placenta and breastfeeding.
 Exposure to TCC during development may pose a health risk to the developing fetuses because they are more sensitive to alterations in hormone levels, which may leads to an irrelevant changes. TCC-related compounds were detected in the tissues of offspring with significantly higher concentrations in the brain, heart and fat.

Quantitative real-time polymerase chain reaction qPCR was used in the study to examine changes in gene expression in liver and adipose tissue in the exposed offspring. The results showed alterations in genes involved in lipid metabolism in exposed female offspring were consistent with the observed increase in fat weights and hepatic triglycerides. Exposed offspring were heavier in weight than unexposed.
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