Eskata for treating Keratoses

Eskata (hydrogen peroxide) 40% (w/w) topical solution is a high-concentration hydrogen peroxide formulation for the treatment of raised seborrheic keratoses.

Seborrheic keratoses (SKs) are non-cancerous skin growths. SKs vary in color from flesh-colored to pink, yellow, gray, tan, brown, or black; can range in size from a millimeter to a few centimeters wide; and typically have a slightly elevated, waxy or scaly appearance.

The number and size of SKs tends to increase with advancing age. SKs frequently appear in highly visible locations, such as the face or neck, but can also appear anywhere on the body, except the palms, soles and mucous membranes.

Eskata is applied by healthcare provider as an in-office treatment and is not for use at home. Serious eye problems can happen if Eskata gets into your eyes. If Eskata accidentally gets into your eyes, flush them well with water for 15 to 30 minutes.

Skin reactions have occurred in and around the treatment area after application of Eskata. Reactions can be severe, including breakdown of the outer layer of the skin (erosion), ulcers, blisters and scarring. The most common side effects of Eskata include itching, stinging, crusting, swelling, redness and scaling.
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Vitamin D enhances healing of burns

Patients with severe burns who have higher levels of vitamin D recover more successfully than those with lower levels. Despite improvements in burn care many patients are still at risk of poor recovery. Complications can range from delayed wound healing through to infections. Patients with severe burns are at high risk of infection that may lead to life-threatening sepsis.

Vitamin D is known to have antibacterial actions that may combat infection and therefore aid in wound healing of burn patients. In order to investigate the role of vitamin D in recovery from burn injuries, researchers assessed the recovery progress, over one year, in patients with severe burns and correlated this with their vitamin D levels.

The study found that patients with higher levels of vitamin D had a better prognosis, with improved wound healing, fewer complications and less scarring. The data also showed that burns patients tend to have lower levels of vitamin D. These data suggest that vitamin D supplementation immediately following burn injury may have potent health benefits to the patient, including enhanced antimicrobial activity to prevent infection, and improved wound healing.

Major burn injury severely reduces vitamin D levels and adding this vitamin back may be a simple, safe and cost-effective way to improve outcomes for burns patients. The effectiveness of vitamin D supplementation to improve outcomes in burn patients would need to be verified in clinical trials.

Low vitamin D levels were associated with worse outcomes in burn patients including life threatening infections, mortality and delayed wound healing . It was also associated with worse scarring but vitamin D levels can improve the healing process.
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