Human immune systems prevents different diseases including cancer, for cancer to spread and multiply, they must find a way to avoid the body's immune system.
Degenerated cells in the body cause an inflammatory reaction and influence other blood cells to the extent that the immune system is suppressed.
Tumor cells influence their environment in order to avoid an immune response and to facilitate their growth. Solid tumors manipulate macrophages of the immune system.
The relationship between leukemia cells and monocytes becomes a catalyst for cancer development. Programmed death-ligand 1PD-L1 also known as cluster receptor occurs more frequently on the surface of these nourishing cells, and suppresses the immune response for cancer to grow.
The immune response is suppressed so much that the cancer cells can multiply without any hindrance. The monocytes send out semiochemicals, which belong to the inflammation response of the immune system and support the growth and multiplication of the cancer cells.
Scientists treated monocytes and macrophages of humans and mice with suspect exosomes, as well as purified Y RNA from those exosomes, in a culture dish. In both cases, the cells changed similarly to how they would in chronic lymphatic leukemia CLL patients.
They carry more PD-L1 receptors to their surface and emit semiochemicals that accelerate the immune response and create favorable growth conditions for leukemia cells.
Adding Toll-like receptors TLR inhibitors such as Chloroquin, a medication used for malaria and rheumatic inflammation can inhibit YRNA.
CLL cells was able to suppress the reproduction of cancer cells markedly.
This makes Chloroquin a good substance for a combination therapy along with other agents for cancer treatment.
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