Stress can cause liver disease

 Endoplasmic reticulum (ER) stress may cause non-alcoholic fatty liver disease, independent of other factors.

When there is nutritional excess, the protein load exceeds the ER folding capacity and a collection of conserved signaling pathways, termed the unfolded protein response (UPR), are activated to preserve ER function.

Research team demonstrated that UPR activation in the forebrain, is linked to non-alcoholic fatty liver disease.

 Brain ER stress can cause the disease independent of changes in
body weight, food intake, and other factors.

Non-alcoholic fatty liver disease impairs normal liver function and is linked to other diseases such as diabetes and cardiovascular disease.

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