The secrets of Ebola

In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone. Conducting a sweeping analysis of everything from enzymes to lipids to immune-system-associated molecules, the teamfound 11 biomarkers that distinguish fatal infections from nonfatal ones and two that, when screened for early symptom onset, accurately predict which patients are likely to die.

Health workers collected blood samples from patients after they were diagnosed with Ebola and at multiple points thereafter.They obtained 29 blood samples from 11 patients who ultimately survived and nine blood samples from nine patients who died from the virus. For comparison, the research team also obtained blood samples from 10 healthy volunteers with no exposure to Ebola virus.
"Our team studied thousands of molecular clues in each of these samples, sifting through extensive data on the activity of genes, proteins and other molecules to identify those of most interest.

The team found that survivors had higher levels of some immune-related molecules, and lower levels of others compared to those who died. Plasma cytokines, which are involved in immunity and stress response, were higher in the blood of people who perished. Fatal cases had unique metabolic responses compared to survivors, higher levels of virus, changes to plasma lipids involved in
processes like blood coagulation, and more pronounced activation of some types of immune cells.

Pancreatic enzymes also leaked into the blood of patients who died, suggesting that damage from these enzymes contributes to the tissue damage characteristic of fatal Ebola virus disease. The study showed that levels of two biomarkers, known as L-threonine (an amino acid) and vitamin D binding protein, may accurately predict which patients live and which die. Both were present at lower levels at the time of admission in the patients who ultimately perished.

When Ebola virus leads to death, experts believe it is because of overwhelming viral replication. Symptoms of infection include severe hemorrhaging, vomiting and diarrhea, fever and more. In the current Ebola study, the team found that many of the molecular signals present in the
blood of sick, infected patients overlap with sepsis, a condition in which the body in response to infection by bacteria or other pathogens mounts a damaging inflammatory reaction.
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Secrets of longevity

Healthy lifestyle is the secret of long life. Seven hours of sleep per night, regular exercise, eating healthy foods and avoiding stressful activities can increase your longevity.

Food is medicine, healthy diet is better than drugs, processed foods contributes to diseases like cancer, diabetes, obesity, high blood pressure and many other terminal diseases.

 You can adopt longevity lifestyle by eating more of plant based healthy diet everyday; start with fruits, vegetables, seeds, whole grains, nuts, legumes and drink enough water. Water is better than any other liquid you know.

Moderate consumption of protein, sugar and refined carbohydrates. Cook with extra virgin olive oil and remember to fast after you feast. Fasting makes insulin sensitive and improves metabolic functions. Eat small portion of food; the less you eat the longer you will live.

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Low carbohydrates diets can imitate effect of ecstasy on your brain

 Low-carb diet changes your metabolic  from burning more carbohydrates to burning of more fat than carbohydrates, this is a process known as ketosis.

When human body uses up carbohydrates glucose reserves, the body stimulates the breakdown of stored fat into fatty acids and releases them into the blood.

When fatty acids reach the liver they are changed into acetoacetate, a metabolic fuel that belongs to a family of ketones.

Acetoacetate decomposes to carbon dioxide and acetone, low-carbohydrates dieters and people who are fasting usually have sweet smelling breath.

A healthy liver minimises the acetone lost through the lungs by converting most of the acetoacetate it produces to beta-hydroxybutyrate BHB. This can cause euphoric feelings.

During ketosis, BHB can reach high levels in the brain, where it can bind to the same anxiety-reducing receptors as recreational drugs with similar effects.
 Side effects of ketosis are loss of calcium from bones, kidney stones and growth retardation.

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How to prevent type 1 diabetes

White blood cells make antibodies against pathogens or other invaders in healthy people. Pancreatic beta cells produce insulin, the hormone that provides fuel to the body's cells by transporting glucose.

 B lymphocytes plays a major role in activating the autoreactive T cells (T lymphocytes) that then destroy the pancreatic beta cells leading to type 1 diabetes.

These damaged cells fail to take glucose into cells, the glucose build up in the blood can damage nerves, blood vessels and organs.

The researchers used a gene manipulation approach to identify a potential metabolic target that would eliminate the B cells that initiate diabetes.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID/RAD51) pathway inhibitor had more of B cells that were capable of suppressing diabetogenic T cell and reduced T1D development.

Antibody production of B cells turn on the gene known as activation-induced cytidine deaminase (AID), which acts as a molecular scissors that cut the chromosomes within the B-cell.

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Whole body vibration therapy may replace regular exercise

Whole body vibration therapy WBVT is a passive form of exercise when something or machine is being used on a person rather than normal activities like walking and running.

WBVT users stand, sit or lay on a machine that vibrates and this process sends energy to the body by contracting and relaxing the muscle several times during the vibration.

WBVT is as good as exercise, it enhances muscle mass and insulin sensitivity in people that use it regularly. It is a useful therapy to combat metabolic dysfunction in people with morbid obesity.