Links between gum disease and cancer

Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists Dominique Michaud at Tufts University School of Medicine and Elizabeth Platz of the Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer Center.

Researchers used data from comprehensive dental exams performed on many participants from Maryland, Minnesota, Mississippi, and North Carolina, as part of their participation in the Atherosclerosis Risk in Communities (ARIC) study who were then followed from the late 1990s until 2012.

 During the follow-up period, 1,648 new cancer cases were diagnosed. The research team found a 24 percent increase in the risk of developing cancer among participants with severe periodontitis, compared to those with mild to no periodontitis at baseline.

Among patients who had no teeth-which can be a sign of severe periodontitis, the increase in risk was 28 percent. The highest risk was observed in cases of lung cancer, followed by colorectal cancer. When the researchers did sub-group analyses, they found that participants with severe periodontal disease had more than double the risk of developing lung cancer, compared with no periodontitis.

An 80 percent increase in risk of colon cancer observed for participants who were edentulous at baseline, which is consistent with prior findings, and among never smokers, a two-fold higher risk was noted for participants with severe periodontitis, compared to those who had no periodontitis.

The research team accounted for the impact of smoking among the participants, since people who smoke are more likely to get periodontal disease, and smoking raises the risk of lung and colon cancers. Looking at data for the people who had never smoked, they also found evidence that having severe periodontal disease was related to an increased risk of lung cancer and colorectal cancer.

The researchers found no links between increased risk of breast, prostate or blood/lymphatic cancer and periodontitis. The link between periodontitis and increased cancer risk was weaker or not apparent in African-American participants from the ARIC study, except in cases of lung and colorectal cancer. Advanced gum disease-periodontitis, is caused by bacterial infection that damages the soft tissue and bone that support the teeth.
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How bacteria prevents ovulation and embryo implanting

Bacteria that causes gum infections can makes conception difficult. Women with bacteria that causes gum disease P. Gingivalis may not become pregnant within 12 months.

Women with the bug, disease of the gum and underlying bone may not become pregnant within 12 months.
Researchers believe that infection in the gums and jawbone leads to inflammation in the body and the inflammation may prevent ovulation.

 Periodontal bacteria may have a systemic effect on conception even before signs of gum disease. Women
of reproductive age are expected to take care of their oral health and attend periodontal evaluations.

Researchers examined 256 healthy non-pregnant women aged between 19 and 42 who had stopped contraception and were trying to get pregnant. The health of their mouths and gums, as well as their reproductive organs, were examined.

 P Gingivalis was detected in the saliva of women who did not become pregnant during the one-year follow-up period than those who became pregnant.

 Researchers discovered that women who either had P. Gingivalis in their saliva or antibodies indicating they had been infected by P Gingivalis, were three times less likely to get pregnant within 12 months.

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How to treat leukemia effectively

Acute lymphoblastic leukemia is a type of cancer in which the bone marrow produces too many immature white blood cells

Activation of a protein called STAT5 causes competition among others that leads to acute lymphoblastic leukemia ALL.

According to new study, competition among some proteins causes an imbalance that leads to leukemia .

Using a drug that will stop the initial activation of STAT5 and reverse the natural balance of protein will leads to effective treatment of acute lymphoblastic leukemia.

Researchers used innovative methodology by combining mouse models and patience samples in high-throughput DNA sequencing, epigenetic and proteomic analysis and discovered that patients with a high ratio of imbalance proteins of STAT5 to IKAROS or NF-KB had worse prognosis.

Insufficient sleep can affect bone formation

Insufficient sleep can cause high blood pressure, heart disease, bone loss and have negative impact on your health.

According to national sleep foundation, the appropriate sleep duration for newborns is between 14 and 17 hours, between 12 and15 hours for infants, 11 and 14 hours for toddlers, 10 and 13 hours  for preschoolers, 9 and 11 hours for school-aged, 8 and 10 hours for teenagers, 7 and 9 hours for young adults and 7 and 8 hours for older adults.

Three weeks of insufficient sleep can reduce levels of marker of bone formation in the blood, because lack of sleep alter bone balance and create a potential bone loss that can cause bone fracture and osteoporosis.

Inadequate sleep is very dangerous for bone formation in children because bone formation at tender age is very important for bone growth and long-term skeletal health in future.