Brain oxidative stress can cause migraine

Migraine are an integrated mechanism by which the brain protects and repairs itself. Migraine can be triggered by diet, stress, sleep disruption, noise and air pollution. It can increase brain oxidative stress, an imbalance between the production of free radicals and the ability of the body to counteract their harmful effects.

Oxidative stress is a useful signal of impending harm because a number of unfavorable conditions in the brain can give rise to it, targeting oxidative stress might prevent or preempt migraines. An interruption in blood supply each of the components is protective: strengthening antioxidant defenses, lowering the production of oxidants, lowering energy requirements and, especially, releasing growth factors into the brain that protect existing neurons and support the birth and development of new neurons.

There are feedback loops between these components of a migraine attack that tie them together into an integrated system, migraine attacks are not triggered by oxidative stress, they actively protect and repair the brain from it. The pain, nausea, and sensitivity to light and sound, fever and pain, or cough are not the disease itself but part of the body's defense against migraine.
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Impact of shift work on your health

According to the latest research, workers who regularly pull overnight shifts may be more prone to accumulation of excess weight. Many workers across the globe follow that work pattern, routinely working a night shift increases the risk of becoming obese or overweight.

Sleep disruption is responsible for the accumulation of excess weight, the human body is programmed to sleep when it is dark, allowing hormones that impact hunger and satiety to reset. When people are awake and working when they should be sleeping, the hormones related to hunger and satiety are active resulting in changes in eating, metabolism and a tendency to eat more than needed.

Sleep deprivation is a major stressor that should be avoided, working night shifts is working against natural biological clocks. According to the International Labour Organization, any schedule that requires working between 12 a.m. and 5 a.m. is considered night-shift work.

The review revealed that workers who are permanently assigned to overnight work are prone to accumulation of excess weight, compared with those who alternate between day and night shifts. The longer a worker engages in regular night-shift work, the higher the risk for gaining weight.

Abdominal obesity is linked to night-shift work, night-shift work is related to metabolic syndrome. The syndrome includes high blood pressure, high cholesterol and high triglyceride levels, and it drives up the risk for developing heart disease, diabetes and stroke.

According to the National Sleep Foundation, wakefulness naturally hits its lowest point between 2 a.m. and 4 a.m., at the center of a standard night shift. Night shifts also challenge a worker's ability to access good food and exercise regularly.
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