FDA Approves Giapreza (angiotensin II) to treat dangerously low blood pressure. Giapreza (angiotensin II) injection for intravenous infusion to increase blood pressure in adults with septic or other distributive shock. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Hypotension is abnormally low blood pressure.
Shock is a critical condition in which blood pressure drops so low that the brain, kidneys and other vital organs can't receive enough blood flow to function properly. In a clinical trial patients with shock and a critically low blood pressure, significantly more patients responded to treatment with Giapreza compared to those treated with placebo.
Giapreza effectively increased blood pressure when added to conventional treatments used to raise blood pressure. The drug can cause dangerous blood clots with serious consequences (clots in arteries and veins, including deep venous thrombosis); prophylactic treatment for blood clots should be used.
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