Education reduces the risk of Alzheimer's disease

The theory that education protects against Alzheimer's disease has been given further weight by new research. Alzheimer's disease is the leading cause of dementia. Building of 'plaques' and 'tangles' of misshapen proteins lead to the gradual death of brain cells. People affected by Alzheimer's experience memory and communication problems, disorientation, changes in behavior and progressive loss of independence.

The causes of Alzheimer's are largely unknown, and attempts to develop drug treatments to stop or reverse its effects have been disappointing. This has led to increasing interest in whether it is possible to reduce the number of cases of Alzheimer's disease by tackling common risk factors that can be modified.

Many studies have shown that the more years spent in full time education, the lower the risk of Alzheimer's. But it is difficult to unravel whether this is an effect of education improving brain function, or whether it's the case that people who are more educated tend to come from more wealthy backgrounds and therefore have a reduction in other risk factors that cause Alzheimer's disease.

Researchers examined looking DNA and compared genes associated with environmental risk factors – for example, genes linked to educational attainment or to smoking – and seeing which of these genes are also associated with Alzheimer's disease. If a gene is associated with both, then it provides strong evidence that this risk factor really does cause the disease. Researchers studied genetic variants that increase the risk of a variety of different environmental risk factors to see if these were more common in patients with Alzheimer's disease. They found the strongest association with genetic variants that predict higher educational attainment.

This provides further strong evidence that education is associated with a reduced risk of Alzheimer's disease, improving education could have a significant effect on reducing the number of people who suffer from this devastating disease. Exactly how education might reduce the risk of Alzheimer's is uncertain.

Previous studies have shown that the same amount of damage in the brain is associated with less severe and less frequent Alzheimer's in people who have received more education. One possible explanation is the idea of 'cognitive reserve' – the ability to recruit alternative brain networks or to use brain structures or networks not normally used to compensate for brain ageing. Evidence suggests that education helps improve brain wiring and networks and hence could increase this reserve.
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