How Parkinson's disease start

Parkinson's disease is a progressive disorder of the nervous system that affects movement.

Bojing Liu of the Karolinska Instituet in Stockholm, Sweden and colleagues discovered that Parkinson's disease might start in the gut and move to the brain through the vagus nerve.

The vagus nerve is the longest cranial nerve, it has motor and sensory fibres because it passes through the neck to the abdomen.

Researchers analyzed registers in Sweden to compare 9,430 people who had a vagotomy over a 40 years to 377,200 people from the general population.

At that time, 101 people who had a vagotomy developed Parkinson's disease. After adjusting for condition
like chronic obstructive pulmonary disease, diabetes, vascular disease, rheumatologic disease and osteoarthritis.

People who had a truncal vagotomy five years earlier may not develop Parkinson's disease compare to those who had not had the surgery.

Those who will develop Parkinson's disease in future have a protein responsible for the disease in there gut.