Lupus increases the risk of dementia

Lupus is a chronic autoimmune disease that causes the body to attack its own healthy cells. It is thought to be caused by genetic and environmental factors. Environmental factors can trigger attacks or 'flare ups. 'Flare ups vary from person to person and are not the same each time. They can be marked by fatigue that can be mild or debilitating. Fatigue is often an early indicator that an attack is about to set in.

Attacks can cause joint and muscle pain and swelling, particularly at the wrists, hands, elbows, knees and ankles. Many people with lupus experience skin problems. The most distinctive marker of lupus is a butterfly-shaped rash on the face. Lupus may also cause light sensitivity, fever, changes in weight and swollen glands. People with lupus sometimes complain of a 'fog,' that can feel like depression or anxiety and sometimes causes them to have difficulty focusing and expressing themselves.

It causes the body’s immune system to break cells in parts of the body including the kidneys, lungs, skin and blood vessels. Lupus may impair memory and cognitive functions. Researchers analyzed data from more than 7,000 people and found that dementia was far more common among people with dementia than those without the disease. Lupus is best known for the damage it does to the kidneys, but its symptoms can be extremely varied, making it very difficult to diagnose.

Experts have identified numerous forms of the disease, including nineteen variations of neuropsychiatric lupus, which affects the central nervous system, including cognitive and memory functions and can even cause psychological and psychiatric symptoms. Some patients refer to a ‘lupus fog,’ a catchall description of the experience of difficulty concentrating, remembering facts, and expressing oneself.

The fog can also come with depression and anxiety, all of which may signal a lupus flare up. Patients who do not have a neuropsychiatric form of lupus are at a greater risk of dementia. Steroids are also associated with memory loss and cognitive impairment in lupus patients.
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