High cholesterol levels have been associated with breast cancer spreading to other parts of the body, researchers discovered that the byproduct of cholesterol metabolism that acts on specific immune cells so that they facilitate the cancer's spread instead of stopping it is responsible for the spread.
Many women will experience metastatic breast cancer, when the breast cancer has spread to other organs, and at that point, there is no effective therapies.
Researchers fed mice with breast cancer tumors a diet high in cholesterol. They confirmed that high levels of cholesterol increased tumor growth and metastasis, and that mice treated with statins cholesterol lowering drugs had less metastasis.
Human body's immune system has the capacity to attack cancer but the cholesterol metabolite hydroxycholestrol 27HC works on immune cells and prevents them from attacking cancer because 27HC acts through the immune system, and not on the breast cancer.
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