Gocovri drug for treatment of dyskinesia

Gocovri (amantadine) drug has been approved for treatment of dyskinesia in patients with Parkinson's disease receiving levodopa-based therapy, with or without concomitant dopaminergic medications.

Gocovri is a high dose 274 mg amantadine (equivalent to 340 mg amantadine HCl) taken once-daily at bedtime that delivers consistently high levels of amantadine from the morning and throughout the day when dyskinesia occurs.

Parkinson's disease is a chronic neurodegenerative disorder. It results from a loss of dopamine in the brain and is commonly treated by levodopa and dopaminergic therapies that replace lost dopamine.

Dyskinesia is a consequence of levodopa-based Parkinson's disease treatment and is characterized by involuntary and non-rhythmic movements that are purposeless and unpredictable, which impact the activities of daily living.

Common adverse reactions of Gocovri are: hallucinations, dizziness, dry mouth, peripheral edema, constipation, fall and orthostatic hypotension.
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Diabetes drug could treat Parkinson’s disease

Taking Exenatide, a diabetes medication increases motor skills than placebo for Parkinson’s disease treatment. The drug could stop decline in Parkinson’s patients rather than providing solution to the symptoms.

The drug activates hormone receptors in the pancreas to stimulate the release of insulin for diabetes patients. But the same receptors exist in the brain, activating them can boost dopamine function and stop inflammation in Parkinson’s disease.

Damage to cells that produced dopamine leads to Parkinson’s disease, preventing the damage could stop the development of the disease.

Parkinson’s patients that used exanatite drug had improved motor function - measures like tremors, agility and speech while those who took the placebo are not getting better.
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Drinking of coffee may increase lifespan

Coffee contains a lot of compounds like caffeine, diterpenes and antioxidants that interact with the body systems and prevent so many diseases.

 It has a lot of antioxidants and phenolic compounds that play an important role in cancer and disease prevention.

Coffee reduces inflammation, controls glucose and strengthens the immune system. Drinking of coffee is associated with a reduced risk of death from circulatory and digestive tract diseases.

 It prevents womb and liver cancer and reduce the risk of Parkinson’s disease, and Alzheimer’s. Moderate drinking of coffee every day is essential for sound health.

Dinking more than 0.4g of caffeine a day can cause anxiety, sleeplessness and disturbed heart rhythm.
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