Engaging in some form of exercise is essential to good health and well-being. It can leads to weight loss, sound sleep, fights stress and high blood pressure, improves mood and strengthen bones and muscles.
Healthy muscles leads to healthy body, it benefits the cellular power plant- the mitochondria which creates the fuel so the body can function properly.
Moderate-to-intense exercise acts as a
stress test on mitochondria in muscles, this triggers mitophagy process where the muscle disposes of the damaged or dysfunctional mitochondria, making the muscle healthier.
Aerobic exercise removes damaged mitochondria in skeletal muscle, doing it repeatedly removes the damaged ones. Researchers assessed the skeletal muscle of a mouse model where they had added a mitochondrial reporter gene called "pMitoTimer."
The mitochondria fluoresce green when they are healthy and turn red when damaged and broken down by the cell's waste-disposal system- the lysosomes.
Researchers observed mice, the mice ran on a small treadmill for minutes and researchers observed mitochondrial stress and some mitophagy after hours of exercise.
Exercise in mice stimulated a kinase called AMPK, which in turn switched on another kinase, Ulk1. These chemical reactions appear to be important in control of the removal of dysfunctional mitochondria. When its turned on, Ulk1 activates other components in the cell to execute the removal of dysfunctional mitochondria.
haleplushearty.blogspot.com
No comments:
Post a Comment