A vaccine that can eradicate the majority of cervical cancer cases shows long-term effectiveness, researchers examined different women in different countries after taking the vaccine the results showed that vaccination with Gardasil 9 can reduce 90 percent of cervical cancers.
The vaccine is unique in its ability to prevent certain cancers. HPV infections cause global disease and deaths. Routine screening by Pap smears or tests for HPV infection has reduced death rates. Vaccination against the sexually transmitted human papillomavirus HPV prevents some cancers.
The vaccine immunizes against nine genotypes of HPV known to cause cervical cancer, as well as vulvar, vaginal and anal cancers and genital warts caused by HPV.
Gardasil vaccine targets the two HPV genotypes that caused about 70 percent of cervical cancer and two other genotypes that cause genital warts. Gardasil 9 targets those four genotypes and five others. Both vaccines are prophylactic, meant to be given before females or males become exposed to HPV infection through intimate contact.
Women were followed for efficacy at preventing disease for up to six years after the first vaccine shots, and they were followed for production of infection-halting antibodies against the nine genotypes of HPV for more than five years.
They were followed by gynecological examination for evidence of infections or disease, and their blood sera were tested for antibody levels against HPV.
Gardasil 9 showed 97.4 percent efficacy to prevent infections and disease caused by the five additional HPV genotypes not included in the four-valent Gardasil vaccine. Gardasil 9 vaccination produced similar antibody protection against the four HPV genotypes in Gardasil.
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