How to target blood vessels to improve cancer Immunotherapy

The aims of cancer immunotherapy is to empower patients immune system T cells to recognize and attack cancer.

Tumors used several methods to fight back immune system attack, like producing blood vessels that hinder arrival of T cells.

Scientists are now reprogramming the tumor blood vessels to treat different types of cancers.

Tumor blood vessels provide oxygen and nutrients to the growing cancer cells,  scientists  used AZV to block the actions of two proteins: VEGFA and ANGPTZ to starve the tumor.

AzV regress and normalized the tumor blood vessels and facilitated the arrival of activated T cells.

Anti-angiogenic drugs like ANGPTZ inhibitors have strong effect on tumor and initiative anti-tumor immune responses.

The link between blood vessels and Immune system

Researchers at Baylor College of Medicine have discovered that tumor blood vessels and immune system influences each other's roles.

There are different therapies for cancer, some therapies stop tumour growth by controlling the blood vessels that protects the tumor mass, others work on the immune system and trying to destroy the tumor.

Anti blood vessel therapies and immunotherapies have been used in treatment of cancer; immunotherapy has record great success in some cancer treatment like melanoma, but some patients are not responding to these therapies.

Researchers suggest consideration of vascular structure of the tumor and the presence of immune cells and their activities. Anti-cancer therapies toward the blood vessels is influencing the anti-tumor immune response and the other way round. Combining the therapies may produce a better result.