Memory performance decreases with increasing age. Cannabis can reverse these ageing processes in the brain. This was shown in mice by scientists at the University of Bonn with their colleagues at The Hebrew University of Jerusalem (Israel).
Old animals were able to regress to the state of two-month-old mice with a prolonged low-dose treatment with a cannabis active ingredient. This opens up new options, for instance, when it comes to treating dementia.
Cognitive ability also decreases with increasing age. This can be noticed, for instance, it becomes more difficult to learn new things or devote attention to several things at the same time and this can leads to dementia.
Researchers have long been looking for ways to slow down or even reverse this process. Scientists at the University of Bonn and The Hebrew University of Jerusalem (Israel) have now achieved this in mice. These animals have a relatively short life expectancy in nature and display pronounced cognitive deficits even at twelve months of age.
The researchers administered a small quantity of THC, the active ingredient in cannabis, to mice aged two, twelve and 18 months for four weeks.
Afterwards, they tested learning capacity and memory performance in the animals -- orientation skills and the recognition of other mice. Mice who were only given a placebo displayed natural age-dependent learning had memory losses.
In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. The treatment completely reversed the loss of performance in the old animals.
Scientists discovered that the brain ages much faster when mice do not possess any functional receptors for THC. These cannabinoid 1 (CB1) receptors are proteins to which the substances dock and thus trigger a signal chain. CB1 is also the reason for the intoxicating effect of THC in cannabis products, such as hashish or marijuana, which accumulate at the receptor.
THC imitates the effect of cannabinoids produced naturally in the body, which fulfil important functions in the brain. With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces.
When the activity of the cannabinoid system declines, we find rapid ageing in the brain. To discover precisely what effect the THC treatment has in old mice, the researchers examined the brain tissue and gene activity of the treated mice.
The molecular signature no longer corresponded to that of old animals, but similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important for learning ability.
A low dose of the administered THC was chosen so that there was no intoxicating effect in the mice. Cannabis products are already permitted as medications, for instance as pain relief. As a next step, the researchers want to conduct a clinical trial to investigate whether THC also reverses ageing processes in human brain and can increase cognitive ability.
